Buy Diane 35 Because it acts directly on the hormones, the treatment is taken daily and at regular times over a period of 21 days. Following this, a 7-day break is completed between the last pack and the new pack. Formulated with a combination of 2 synthetic hormones, Diane 35 is therefore similar to a monophasic contraceptive pill. Pills can be taken either at meal times or not. It is however easier to swallow the pill with a glass of water.